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«Наука через призму времени»
Май, 2023 / Международный научный журнал
«Наука через призму времени» №5 (74) 2023
Автор: Gaybullaev Javlon Shavkatovich, ассистент
Рубрика: Медицинские науки
Название статьи: Acute myocarditis in children on the background of broncho-pulmonary diseases
Дата публикации: 30.04.2023
ACUTE MYOCARDITIS IN CHILDREN ON THE BACKGROUND OF BRONCHO-PULMONARY
DISEASES
Gaybullaev Javlon Shavkatovich
assistant of the Department of 1 Pediatrics and
Neonatology,
Samarkand State Medical University, Samarkand, Uzbekistan
Abstract. Broncho-pulmonary
diseases in children is one of the urgent problems in pediatrics, which is determined by the
continuing high incidence and severe prognosis, especially in young children.
The aim of the study was to determine the clinical characteristics of acute myocarditis in children with acute broncho-pulmonary
diseases. We examined 64 children aged 6 months to 7 years with broncho-pulmonary diseases, which we divided into 2 groups.
Group I (control) included 32 children who had only respiratory complaints.
Group II (main) included 32 sick children with broncho-pulmonary
diseases, who had a violation of the cardiovascular system, the presence of
which was confirmed by instrumental methods. The results obtained emphasize
that against the background of broncho-pulmonary
diseases, all symptoms of acute heart failure are masked, the cause of which in
most cases is acute coronary insufficiency; changes in the heart muscle in this
pathology in children increases the risk of severe unwanted heart
complications.
Key words: acute myocarditis, broncho-pulmonary
diseases, children.
Relevance. For several decades, severe broncho-pulmonary diseases has remained one of the urgent
problems of modern medicine due to the steady trend towards an increase in the
number of patients and a consistently high mortality rate, despite the use of
new principles and methods of treatment [3,4]. The probable reason for this is
the delayed diagnosis and, as a consequence, late initiation of treatment, as
well as the impossibility of conducting an adequate assessment of the
effectiveness of therapy. The diagnosis of broncho-pulmonary
diseases in children is often difficult, especially if signs of respiratory
failure have developed against the background of ARVI. The problem of acute myocarditis is currently due to its widespread occurrence,
especially in childhood.
One of the main causes of acute myocarditis today is acute respiratory viral infections
(ARVI), which remain the most common and global diseases in children.
Cardiovascular failure is common in broncho-pulmonary
diseases, especially in young children. It develops rapidly, already in the
early stages of the disease. With an uncomplicated course of the disease,
clinically latent heart failure occurs, it is
diagnosed with the help of instrumental studies such as ECG, Echo CG. Withbroncho-pulmonary diseases in children, dysfunction of
the cardiovascular system can clinically manifest itself in the form of
coronary insufficiency, and more often cardiovascular failure. [2,7.9,]. Each flu epidemic accompanied with a complication of
broncho-pulmonary diseases in children is associated
with an increase in the number of cases of acute myocarditis,
which determines the urgency of studying this problem.
An even more serious task is the timely
diagnosis of complications of broncho-pulmonary
diseases, especially myocarditis, since the
identification of this cardiac complication allows you to avoid severe and
sometimes fatal consequences for the patient. Previously developed clinical
criteria, diagnostic criteria for the diagnosis of heart failure are not always
objective enough to identify circulatory disorders in young children. For
example, anxiety, decreased appetite, poor sleep in children
are almost always noted. Tachypnea and
tachycardia can be not only a sign of broncho-pulmonary
diseases, but also occur in a healthy child during examination, feeding, etc.
Shortness of breath, tachypnea are always accompanied
by diseases of the bronchi and lungs. The frequency of myocarditis
in Broncho-pulmonary diseases according to different
authors varies from 1 to 15%. From a diagnostic point of view, there are no specific electrocardiographic
changes characteristic only for myocarditis.
Myocarditis is an inflammatory lesion of the heart
muscle of an infectious, toxic-infectious, infectious-allergic, autoimmune and
toxic etiology [6]. This disease is predominantly of children and young people,
although the disease can develop at any age. Any viral or bacterial agents, as well
as non-infectious factors, can be the cause of myocarditis.
The most common cause of the disease is viruses. In 6-8% of cases, myocarditis develops during or shortly after various
sporadic or epidemic viral infections [1].
Of the bacterial myocarditis,
the most dangerous are diphtheria (infectious toxic), myocarditis
with scarlet fever, typhoid fever and salmonellosis,
tuberculosis, yersiniosis (intestinal and pseudotuberculosis), with generalized streptococcal and
staphylococcal infections, 10 pathogens associated with these [8]
Purpose.To determine the
clinical characteristics of acute myocarditis in
children with broncho-pulmonary diseases.
Materials and research methods. We examined children aged 6 months to 7
years with broncho-pulmonary diseases, who were
hospitalized in the emergency pediatrics and children's intensive care units of
the SB of RSCEMA. The average age of the examined children was 2.7 years old.
The exclusion criteria were: a previous infectious disease within a month
before hospitalization, the presence of organic heart disease (congenital and
acquired heart defects, cardiomyopathy), the presence
of signs of rheumatic fever and coronary artery disease. A total of 64 patients
with broncho-pulmonary diseases who met the exclusion
criteria were included in the study.
The patients were randomly divided into 2
groups Group I (control) included 32 children who had only respiratory
complaints. Group II (main) included 32
sick children with broncho-pulmonary diseases, who
had a violation of the cardiovascular system.
Evaluation of the effectiveness of the
therapy for broncho-pulmonary diseases according to
the standard was carried out on the basis of objective signs of cyanosis,
congestive wheezing in the lungs and tachycardia. Assessment of the severity of
cyanosis in patients was assessed by central and peripheral distribution, and
cough by a 4-point system: 0 points - no cough, 1 point - a single cough, 2
points - moderately expressed cough and 3 points - frequent, painful cough.
Tachycardia and cyanosis were the main signs of heart damage in Broncho-pulmonary diseases, which tended to continue even
against the background of the disappearance of intoxication from the underlying
disease.
Additional criteria for the effectiveness
of therapy were the duration of oxygen therapy and the duration of
hospitalization. Patient management was carried out in accordance with the
specifics of the Emergency Medical Service, diagnostic and treatment standards
(the recommended deadlines for inpatient treatment of bronchopulmonary
diseases were observed). Discharge criteria were: satisfactory condition, SpO2 ≥95%,
reduction in cough, shortness of breath and tachycardia. The presence of
changes in the electrocardiographic study of
"metabolic nature" according to the conclusion of the cardiologist
and insignificant preserved oral cyanosis were not a contraindication for
discharge. The observation of the patients continued until the main symptoms of
the disease were completely resolved.
Research results and discussion.After the study, the main indicators of
patients in the compared groups were analyzed and compared at admission to the
hospital. The analysis showed that the patients selected for the main and
control groups were comparable in terms of gender, age, target
indicators. Upon repeated examination of children with cardiac disorders at
discharge, the following hemodynamic parameters
remained: LVEF in the treatment group decreased 45.6 ± 9.6% to 26 ± 6.7% to in the placebo group,
where there was a decrease in EF from 27.7 ± 5.6% to 21.3 ± 5.3%; of course,
the diastolic volume in the treatment group decreased from 25.7 ± 50.1 to 140.7
± 50.6 vs in the placebo group, where EDV increased
from 245 ± 46.3 to 280.6 ± 48.9. The most frequent changes recorded on the ECG
are sinus.tachycardia, which was noted in 18(39.1%)
patients, ST segment changes in 12, AV block in 4(8,7%), left bundle branch
block in 22(47,8%) patients. Thus, the most valuable electrocardiographic
parameter in patients with myocarditis , is a change in the QRS complex.
The results of our study show that it is
necessary to conduct echo cardiographic, as well as electrocardiographic studies of children with broncho-pulmonary diseases, causes a decrease in
complicated cardiorespiratory syndromes and post
hypoxic changes in the ventricular myocardium, which allows us to conclude that
there is a certain advantage of preventive examination to prevent the
development of chronic cardiovascular pathology. The most frequent changes
recorded on the ECG were sinus tachycardia, which was noted in 18 (39.1%)
patients, ST segment changes in 12, AV block in 4 (8.7%), left bundle branch
block in 22 (47 , 8%) patients.
Studies have shown that at present, the
criteria for early detection of cardiac pathology in patients with broncho-pulmonary diseaseshave
not been sufficiently developed. Due to the fact that the number of cardiac
pathology at autopsy significantly exceeds its lifetime detection, the problem
of early diagnosis of cardiovascular pathology and risk factors for its
development in sick children with broncho-pulmonary
diseases remains an urgent issue of clinical medicine [4].
Among the pulmonary and extrapulmonary complications of broncho-pulmonary
diseases, an important place is occupied by lesions of the cardiovascular
system [2,4]. According to many authors [1,10],
dysfunction of the cardiovascular system is an almost constant companion of broncho-pulmonary diseases and develops from the first
hours; at the same time, circulatory disorders often determine the prognosis
and outcome of broncho-pulmonary diseases itself.
Conclusion. Thus, the clinical manifestations of
heart failure in early childhood are non-specific, which in order to clarify
the diagnosis, it is necessary to conduct a complete clinical and instrumental
study, including an ECG with the calculation of indicators of central hemodynamics. An echocardiographic
study of children with broncho-pulmonary diseases
leads to a decrease in complicated cardiorespiratory
syndromes and post-hypocal changes in the ventricular
myocardium, which allows us to conclude that there is a certain advantage of
preventive examination to prevent the development of chronic cardiovascular
pathology under the "mask" of broncho-pulmonary
diseases in children and further transformation of the disease into various cardiopathy.
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